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proton-pump inhibitors in percutaneous coronary intervention for patients receiving clopidogrel, clinical trials results

omeprazole versus placebo
COGENT, 2009
NCT00557921
CGT-2168 (75-mg clopidogrel with 20 mg of omeprazole) once daily
versus
placebo
patients requiring clopidogrel for at least 12 months, typically following non-ST-segment-elevation ACS, STEMI, or stent implantationdouble blind
Follow-up duration: 133 days (mean)
US, Canada, Mexico, Australia, Chile, and Europe
OCLA, 2008
NCT00349661
omeprazole 20 mg daily
versus
placebo
patients undergoing coronary artery stent implantationdouble blind
Follow-up duration: 7 days
France
pantoprazole versus omeprazole
PACA, 2009
pantoprazole 20 mg
versus
omeprazole 20 mg
patients undergoing coronary stenting for non–ST-segment elevation acute coronary syndrome
Follow-up duration: 1 mo

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